Cong Li

Professor, doctoral tutor, vice president of research

Education: PhD

Email： congli@fudan.edu.cn

Tel： 021 5198 0100

Add: School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong New Area, Shanghai

2001.04 – 2004.10 Ph.D., Department of Chemistry, University of Hong Kong
1997.09 – 2000.07 Master of Chemistry, Wuhan University
1993.09 – 1997.07 Bachelor degree in Chemistry, Wuhan University

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Professor, New Century Talents of the Ministry of Education, Shanghai Education Commission Shuguang Planning Talents, Zhangjiang Talents, Shanghai Youth Science and Technology Talents

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The research work focuses on the key scientific issues of "the evolution and regulation mechanism of blood-brain barrier structure in glioma infiltrates". It is difficult to accurately locate glioma, "difficult to complete resection", "difficult to treat", and difficult to relapse control. "Study on clinical dilemmas." The main results are as follows:1. To solve the problem of glioma boundary determination in surgery, a pH bimodal signal synchronous response probe was constructed to trace the "metabolic boundary" of glioma by tracing the acidic environment of tumor, which is more than the clinical structure. The imaging boundary more accurately depicts the infiltrating area of ??glioma; 2. The adenosine receptor agonist is constructed to prevent the blood-brain barrier from hindering the drug into the brain, revealing the endogenous nature of the tight junction between the vascular endothelial cells Signal transduction mechanism; 3. It was found that the elimination of intracellular including hydrogen peroxide under pathological conditions can promote the phenotypic polarization of microglia, revealing that ROS regulates the phenotypic polarization of microglia. The key role played a new way to achieve rebalization of glioma immune microenvironment and improve the response rate of immunotherapy.

In the past five years (since 2013), 19 authors have published SCI papers in mainstream journals such as Adv Mater, Angew Chem Int Ed, ACS Nano, Chem Sci, Theranostics, Small, Int J Cancer, J Cereb Blood Flow & Metab. 9 IF 8.0 or higher, 3 IF 10.0 or higher. He was awarded the honorary title of New Century Talents of the Ministry of Education (2013), Shanghai Youth Science and Technology Talents (2016), Shanghai Shuguang Talent (2015) and Zhangjiang Talents (2016). The series of "Glucosamine-Blood-Brain Barrier Regulation" won the second prize of National Science and Technology Progress Award (ranked 2nd, 2015), the first prize of Science and Technology Progress of the Ministry of Education (ranked 5th, 2011), and the second prize of Shanghai Science and Technology Progress Award. (ranked 5th, 2014). He is currently a member of the Chinese Medical Doctor Association-Mental Glioma Professional Committee, the Chinese Biomedical Engineering Society-Deputy Secretary-General of the Biophotonics Professional Committee, the Shanghai Nuclear Society-Deputy Director of the Nuclear Medicine and Nuclear Pharmacy Committee, and the Chinese Biophysical Society-Molecular Imaging Young professional committee members of the Academic Committee.

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National Natural Science Foundation of China, the pH ratio response type near-infrared fluorescent probe for dynamic monitoring of mitochondrial autophagy, project leader, No. 81771895, 2018-2021
National Natural Science Foundation of China, image guidance of nano-agonist function optimization to improve the neuroprotective effect of ischemic stroke, project leader, No. 81571741, 2016-2019;
National Natural Science Foundation of China, targeted regulation of blood-brain barrier permeability to achieve image-guided brain tumor delivery, project leader, No.81371624, 2014-2017;
National Natural Science Foundation of China, a tumor-targeted "smart" type near-infrared fluorescent probe with pH-stress ability, project leader, No.81171384, 2012-2015;
National Natural Science Foundation of China Youth Fund Project, siRNA gene interference and enzymatic prodrug cancer synergy therapy under the guidance of non-invasive medical imaging, project leader, No.30900353, 2010-2012;
New Century Excellent Talents of the Ministry of Education, Molecular Imaging and Molecular Probes, Project Leader, 2013-2015;
The establishment of experimental animal specialties in the basic research field of Shanghai Science and Technology Commission, the establishment of non-invasive transparent mouse dorsal dorsum window and its application in tumor microenvironment imaging, project leader, No. 15140901300, 2015-2017
Shanghai Science and Technology Commission, the basic research field of nano-specialty, trans-blood-brain barrier nano-probe to achieve early diagnosis of brain tumors and video guidance, project leader, No. 12NM0501400, 2012-2015
National Major Scientific Research Program - Nano Research Project, Research Key, No.2013CB932502, 2013-2017
National Major Scientific Research Program - Protein Research Special, Research Key, No.2011CB910404, 2011-2015

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2016-present Chinese Medical Association-Glioma Professional ，Committee
2015-present China National Institute of Biomedical Engineering - Biophotonics Professional Committee， Member and Deputy Secretary General
2015-present The Shanghai Nuclear Society，Member
2011-Present The Chinese Society of Biophysics - Molecular Imaging Professional Committee，Member

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